Prevention of macrophage-related inflammatory diseases by allergina

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Prevention of macrophage-related inflammatory diseases by allergina
Sang Bae Han; Chang Woo Lee; Song Kyu Park; Woon Kee YoonJae Sun MoonKi Hoon LeeHyoung-Chin Kim; Hwan Mook Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 26, no. 4, pp. 312-316
Publication Year
The oriental herbal combination allergina has been shown to inhibit allergic inflammation. In the present study, we demonstrate that the oral administration of allergina markedly inhibits the progression of inflammatory diseases, such as graft-versus-host diseases (in the allogeneic bone marrow transplantation and the parent-into-F1 transplantation models), collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity. The immunosuppressive activity of allergina in vivo appears to be associated, at least in part, with the inhibition of tumor necrosis factor-α production. In conclusion, our results suggest that allergina could be useful as a immunosuppressive agent for the treatment of macrophage-related inflammatory disease.
allerginacollagen-induced arthritisdelayed type hypersensitivitygraft-versus-host diseases
Pharmaceutical Soc Korea
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Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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