Reprogramming DNA methylation in the preimplantation stage: peeping with Dolly's eyes

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dc.contributor.authorYong Kook Kang-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorYong Mahn Han-
dc.date.accessioned2017-04-19T08:59:57Z-
dc.date.available2017-04-19T08:59:57Z-
dc.date.issued2003-
dc.identifier.issn0955-0674-
dc.identifier.uri10.1016/S0955-0674(03)00031-0ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6137-
dc.description.abstractOocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown. Aberrant epigenetic phenomena in early cloned embryos indicate that parts of the somatic cell genome are unyielding to reprogramming forces, owing to their 'knotty' epigenetic features. This fastidious nature of the donor genome might prevent completion of epigenetic reprogramming. It might also help to explain the chronic developmental defects seen in many cloned embryos.-
dc.publisherCurrent Biology Ltd-
dc.titleReprogramming DNA methylation in the preimplantation stage: peeping with Dolly's eyes-
dc.title.alternativeReprogramming DNA methylation in the preimplantation stage: peeping with Dolly's eyes-
dc.typeArticle-
dc.citation.titleCurrent Opinion in Cell Biology-
dc.citation.number3-
dc.citation.endPage295-
dc.citation.startPage290-
dc.citation.volume15-
dc.contributor.affiliatedAuthorYong Kook Kang-
dc.contributor.affiliatedAuthorKyung Kwang Lee-
dc.contributor.affiliatedAuthorYong Mahn Han-
dc.contributor.alternativeName강용국-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeName한용만-
dc.identifier.bibliographicCitationCurrent Opinion in Cell Biology, vol. 15, no. 3, pp. 290-295-
dc.identifier.doi10.1016/S0955-0674(03)00031-0-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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