Mechanistic study of the intramolecular conversion of maltose to trehalose by Thermus caldophilus GK24 trehalose synthase

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Title
Mechanistic study of the intramolecular conversion of maltose to trehalose by Thermus caldophilus GK24 trehalose synthase
Author(s)
Suk Hoon Koh; Joong Su Kim; H J Shin; Duck Hee Lee; Jung Don Bae; Doo Il Kim; Dae Sil Lee
Bibliographic Citation
Carbohydrate Research, vol. 338, no. 12, pp. 1339-1343
Publication Year
2003
Abstract
This paper questions what types of molecular transformation are involved in the conversion of maltose to trehalose by trehalose synthase from Thermus caldophilus GK24. The reverse reaction pathway has been examined with the aid of α,α-(2,4,6,6′,2′,4′,6″,6?- 2H8)trehalose (1). The mass data of the isolated reaction products clearly indicate that deuterated glucose is confined only to substrate molecules, and thus the reversible enzymatic conversion of trehalose into maltose proceeds through an intramolecular pathway.
Keyword
Intramolecular conversionReaction mechanismThermus caldophilusTrehaloseTrehalose synthase
ISSN
0008-6215
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0008-6215(03)00172-1
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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