Torilin from Torilis japonica, as a new inhibitor of testosterone 5α-reductase

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dc.contributor.authorW S Park-
dc.contributor.authorE D Son-
dc.contributor.authorG W Nam-
dc.contributor.authorS H Kim-
dc.contributor.authorM S Noh-
dc.contributor.authorB G Lee-
dc.contributor.authorI S Jang-
dc.contributor.authorSe Eun Kim-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorC H Lee-
dc.date.accessioned2017-04-19T09:00:00Z-
dc.date.available2017-04-19T09:00:00Z-
dc.date.issued2003-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2003-39717ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6159-
dc.description.abstractThe methanolic extract of the fruits of Torilis japonica showed a potent inhibition against 5α-reductase activity in vitro. Bioassay-guided fractionation of the methanol extract of the fruits followed by repeated silica gel chromatography led to the isolation of an active principle and its structure was identified as torilin on the basis of spectroscopic data. Torilin (IC50 = 31.7 ± 4.23 μM) showed a stronger inhibition of 5α-reductase than α-linolenic acid (IC50 = 160.3 ± 24.62 μM) but was weaker than finasteride. (IC50 = 0.38 ± 0.06 μM). Simple guaiane-type compounds, such as (-)-guaiol and guaiazulene showed weak inhibitory effects on the 5α-reductase activity with IC50 values of f 81.6 μM and 100.8 μM, respectively, while azulene was not active. These results suggest that both degrees of unsaturation and the side-chain in the guaiane skeleton are important for the manifestation of 5α-reductase inhibition.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleTorilin from Torilis japonica, as a new inhibitor of testosterone 5α-reductase-
dc.title.alternativeTorilin from Torilis japonica, as a new inhibitor of testosterone 5α-reductase-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number5-
dc.citation.endPage461-
dc.citation.startPage459-
dc.citation.volume69-
dc.contributor.affiliatedAuthorSe Eun Kim-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeName박원석-
dc.contributor.alternativeName손의동-
dc.contributor.alternativeName남계원-
dc.contributor.alternativeName김수현-
dc.contributor.alternativeName노민수-
dc.contributor.alternativeName이병건-
dc.contributor.alternativeName장이섭-
dc.contributor.alternativeName김세은-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName이창훈-
dc.identifier.bibliographicCitationPlanta Medica, vol. 69, no. 5, pp. 459-461-
dc.identifier.doi10.1055/s-2003-39717-
dc.description.journalClassY-
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