Suppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney

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dc.contributor.authorY K Choi-
dc.contributor.authorY J Kim-
dc.contributor.authorH S Park-
dc.contributor.authorK Choi-
dc.contributor.authorS G Park-
dc.contributor.authorYoung Ik Lee-
dc.contributor.authorJ G Park-
dc.date.accessioned2017-04-19T09:00:06Z-
dc.date.available2017-04-19T09:00:06Z-
dc.date.issued2003-
dc.identifier.issn0969-7128-
dc.identifier.uri10.1038/sj.gt.3301926ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6174-
dc.description.abstractGlomerulosclerosis is a common morphologic result seen in almost all progressed renal diseases, and is the characteristic change in focal segmental glomerulosclerosis (FSGS). The most convincing hypothesis for glomerulosclerosis is cytokine-mediated injury by infiltrating immune cells in the glomerulus and tubulointerstitial area. This study investigated whether the anti-inflammatory effect of interleukin-10 (IL-10) when expressed by a recombinant adenoviral vector can prevent the onset of glomerulosclerosis in FGS/Kist mice (an animal model with naturally occurring renal failure initiated by FSGS). Each group of mice received recombinant adenoviruses encoding human IL-10 (Ad:hIL-10) by intraparenchymal injection at 6 weeks and were examined for cytokine expression, glomerular sclerotic index, and proteinuria. After injection of Ad:hIL-10 to the kidney, IL-10 expression was found to last over 20 days. Mice treated with Ad:hIL-10 were shown to have a significant reduction in the glomerular sclerotic index at 10 weeks when compared to control groups. The level of proteinuria in Ad:hIL-10-treated mice was also significantly reduced. About 50% of the urine samples of naive and Ad:LacZ-treated groups had severe levels of proteinuria. By contrast, at 10 weeks the group treated with Ad:hIL-10 had lower levels of proteinuria and transforming growth factor-β1 (TGF-β1) expression. These results demonstrate that IL-10 effectively prevents the development of glomerulosclerosis in FGS/Kist mice, and IL-10 gene therapy may be of use for the treatment of renal failure.-
dc.publisherSpringer-Nature Pub Group-
dc.titleSuppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney-
dc.title.alternativeSuppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney-
dc.typeArticle-
dc.citation.titleGene Therapy-
dc.citation.number7-
dc.citation.endPage568-
dc.citation.startPage559-
dc.citation.volume10-
dc.contributor.affiliatedAuthorYoung Ik Lee-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName-
dc.contributor.alternativeName박승길-
dc.contributor.alternativeName이영익-
dc.contributor.alternativeName박종구-
dc.identifier.bibliographicCitationGene Therapy, vol. 10, no. 7, pp. 559-568-
dc.identifier.doi10.1038/sj.gt.3301926-
dc.subject.keywordadenovirus-
dc.subject.keywordfocal segmental glomerulosclerosis-
dc.subject.keywordinterleukin-10-
dc.subject.localAdenovirus-
dc.subject.localadenovirus-
dc.subject.localFocal segmental glomerulosclerosis-
dc.subject.localfocal segmental glomerulosclerosis-
dc.subject.localInterleukin-10-
dc.subject.localinterleukin-10-
dc.description.journalClassY-
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