Pseudopolymorphic crystallization of L-ornithine-L-aspartate by drowning out

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Title
Pseudopolymorphic crystallization of L-ornithine-L-aspartate by drowning out
Author(s)
Y H Kim; S J Haam; Y G Shul; W S Kim; Joon Ki Jung; H C Eun; K K Koo
Bibliographic Citation
Industrial & Engineering Chemistry Research, vol. 42, no. 4, pp. 883-889
Publication Year
2003
Abstract
Crystallization of L-ornithine-L-aspartate (LOLA) by drowning out was investigated using methanol as an antisolvent for the production of the anhydrous form of LOLA. An initial mixing method of the LOLA aqueous solution with methanol was found to be a critical factor in the pseudopolymorphic crystallization of LOLA. When methanol was added into the LOLA aqueous solution, it was found that the crystal structure of LOLA was mainly determined by the operating temperature. At a temperature higher than about 60 °C, the anhydrous form of LOLA was always formed. However, at a temperature lower than 50 °C, only LOLA hydrate was produced. On the other hand, when the LOLA aqueous solution was added into methanol, the anhydrous form was obtained by controlling the operational temperature, the feeding rate of the LOLA aqueous solution, and the methanol concentration even at a temperature lower than 50 °C.
ISSN
0888-5885
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/ie020432d
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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