Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-κB-dependent inflammatory mediators in hyperlipidemic mice

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Title
Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-κB-dependent inflammatory mediators in hyperlipidemic mice
Author(s)
J H Choi; Tae Sook Jeong; D Y Kim; Y M Kim; H J Na; Ki Hoan Nam; Sae Bom Lee; Hyoung-Chin KimSei Ryang Oh; Yang Kyu Choi; Song Hae Bok; Goo Taeg Oh
Bibliographic Citation
Journal of Cardiovascular Pharmacology, vol. 42, no. 2, pp. 287-295
Publication Year
2003
Abstract
Hematein, a natural compound, is a known antiinflammatory and antiatherogenic agent in the rabbit model. The authors investigated the effects of this compound on atherogenesis and possible mechanisms of the actions in the hyperlipidemic mice. Low-density lipoprotein receptor-deficient (Ldlr-/-) mice fed a high-cholesterol diet alone for 8 weeks developed the fatty streak lesion in the aortic sinus, whereas this lesion was significantly reduced by hematein treatment without a change in plasma lipid levels compared with control mice. Hematein treatment reduced plasma levels of lipid peroxide and superoxide generation in LPS-stimulated peritoneal macrophage. Hematein treatment inhibited NF-κB-DNA binding activity in peritoneal macrophages from Ldlr-/- mice and the activation of NF-κB in RAW264.7 macrophages. This compound suppressed plasma nitrite/nitrate levels in Ldlr-/- mice and NO production and iNOS expression in LPS+IFNγ-stimulated peritoneal macrophages. Hematein treatment also suppressed the activity of iNOS promoters in RAW264.7 macrophages, and reduced the plasma levels of TNF-α and IL-1β and the production of these cytokines in LPS+IFNγ-stimulated peritoneal macrophages. These results suggest that hematein inhibits atherosclerotic lesion formation, possibly by reducing proinflammatory mediators through a decrease in reactive oxygen species generation and NF-κB activation.
Keyword
Anti-inflammationAntiatherogenesisHemateinNF-κBReactive oxygen species
ISSN
0160-2446
Publisher
Kluwer
DOI
http://dx.doi.org/10.1097/00005344-200308000-00019
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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