Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells

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dc.contributor.authorJong Soon Kang-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorKyu-Hwan Yang-
dc.contributor.authorHwan Mook Kim-
dc.date.accessioned2017-04-19T09:00:12Z-
dc.date.available2017-04-19T09:00:12Z-
dc.date.issued2003-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/S0014-5793(03)00827-5ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6208-
dc.description.abstractSilymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-α-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-α-induced DNA binding of NF-κB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules.-
dc.publisherWiley-
dc.titleSilymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells-
dc.title.alternativeSilymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number1-
dc.citation.endPage93-
dc.citation.startPage89-
dc.citation.volume550-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.affiliatedAuthorKyu-Hwan Yang-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName양규환-
dc.contributor.alternativeName김환묵-
dc.identifier.bibliographicCitationFEBS Letters, vol. 550, no. 1, pp. 89-93-
dc.identifier.doi10.1016/S0014-5793(03)00827-5-
dc.subject.keyworde-selectin-
dc.subject.keywordICAM-1-
dc.subject.keywordNF-κB/Rel-
dc.subject.keywordsilymarin-
dc.subject.keywordVCAM-1-
dc.subject.localE-selectin-
dc.subject.locale-selectin-
dc.subject.localICAM-1-
dc.subject.localNF-κB/Rel-
dc.subject.localSilymarin-
dc.subject.localsilymarin-
dc.subject.localVCAM-1-
dc.description.journalClassY-
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