DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | Kyu-Hwan Yang | - |
dc.contributor.author | Hwan Mook Kim | - |
dc.date.accessioned | 2017-04-19T09:00:12Z | - |
dc.date.available | 2017-04-19T09:00:12Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | 10.1016/S0014-5793(03)00827-5 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6208 | - |
dc.description.abstract | Silymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-α-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-α-induced DNA binding of NF-κB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules. | - |
dc.publisher | Wiley | - |
dc.title | Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells | - |
dc.title.alternative | Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells | - |
dc.type | Article | - |
dc.citation.title | FEBS Letters | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 93 | - |
dc.citation.startPage | 89 | - |
dc.citation.volume | 550 | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.affiliatedAuthor | Kyu-Hwan Yang | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 양규환 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.identifier.bibliographicCitation | FEBS Letters, vol. 550, no. 1, pp. 89-93 | - |
dc.identifier.doi | 10.1016/S0014-5793(03)00827-5 | - |
dc.subject.keyword | e-selectin | - |
dc.subject.keyword | ICAM-1 | - |
dc.subject.keyword | NF-κB/Rel | - |
dc.subject.keyword | silymarin | - |
dc.subject.keyword | VCAM-1 | - |
dc.subject.local | E-selectin | - |
dc.subject.local | e-selectin | - |
dc.subject.local | ICAM-1 | - |
dc.subject.local | NF-κB/Rel | - |
dc.subject.local | Silymarin | - |
dc.subject.local | silymarin | - |
dc.subject.local | VCAM-1 | - |
dc.description.journalClass | Y | - |
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