Melanin biosynthesis inhibitory activites of coumarins isolated from Angelica polymorpha MAXIM = 궁궁이(Angelica polymorpha MAXIM)로부터 분리한 coumarin 계열 화합물의 melanin 생합성 억제 활성

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Title
Melanin biosynthesis inhibitory activites of coumarins isolated from Angelica polymorpha MAXIM = 궁궁이(Angelica polymorpha MAXIM)로부터 분리한 coumarin 계열 화합물의 melanin 생합성 억제 활성
Author(s)
Seung Hwa Baek; Jin Hee Kim; Hyun A Kim; Sang Myung Lee; C Y Lee; Yung Hee Kho; Choong Hwan Lee
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 31, no. 2, pp. 135-139
Publication Year
2003
Abstract
During the screening for inhibitors of melanin biosynthesis from plant extract, Angelica polymorpha MAXIM which showed a high level of inhibition was selected. The inhibiting substances were purified form methanol extract of Angelica polymorpha MAXIM followed by silica gel column chromatography and HPLC. The inhibitors were identified as heraclenin, isosaxalin and heraclenol 3′-Me ether, by spectroscopic methods of ESI-MS, 1H-NMR, 13C-NMR, DEPT, HMQC and HMBC. These compounds did not have mushroom tyrosinase inhibitory activity, but showed a highly potent melanin biosynthesis inhibition zone in the plate culture of Streptomyces bikiniensis, a bacterium used as an indicator organism in this work. These compounds did not show any growth inhibition against S. bikiniensis at the same concentration of melanin biosynthesis test.
Keyword
melanin biosynthesisinhibition zonestreptomyces bikiniensisangelica polymorpha MAXIM
ISSN
0257-2389
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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