Antioxidant activity of two phloroglucinol derivatives from Dryopteris crassirhizoma

Cited 65 time in scopus
Metadata Downloads
Title
Antioxidant activity of two phloroglucinol derivatives from Dryopteris crassirhizoma
Author(s)
Sang Myung Lee; M K Na; Ren Bo An; Byung Sun Min; Hyeong Kyu Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 26, no. 9, pp. 1354-1356
Publication Year
2003
Abstract
The rhizome of Dryopteris crassirhizoma NAKAI exhibited significant antioxidant activity, as assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity in vitro. Two phloroglucinol derivatives, flavaspidic acids PB (1) and AB (2), were isolated from the rhizome of D. crassirhizoma by a bioassay-guided fractionation. 1H-, 13C-NMR, and UV analysis were used to determine the structures. Furthermore, the two compounds were tested for their antioxidant activities, such as their DPPH radical scavenging, superoxide radical scavenging, and lipid peroxidation (LPO) inhibitory activities. Compounds 1 and 2 exhibited potent antioxidant activity against the LPO inhibitory test with IC50 values of 12.9 and 13.1 μM, respectively, compared with α-tocopherol (IC 50; 15.6 μM) and butylated hydroxy anisole (BHA, IC50; 10.8 μM), while the two compounds had a moderated effect on the DPPH radical scavenging activity (IC50; 71.7, 76.3 μM) as well as superoxide radical scavenging activity (IC50; 58.6, 64.4 μM). The potent activity of the flavaspidic acids (1, 2) on inhibiting LPO might be due to possible stabilization as a result of chelating with iron.
Keyword
Antioxidant activityDryopteris crassirhizomaFlavaspidic acid ABFlavaspidic acid PB
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.26.1354
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.