Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma

Cited 51 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSang Myung Lee-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorY Zhang-
dc.contributor.authorRen Bo An-
dc.contributor.authorByung Sun Min-
dc.contributor.authorHyouk Joung-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T09:00:16Z-
dc.date.available2017-04-19T09:00:16Z-
dc.date.issued2003-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6238-
dc.description.abstractFour protostane-type triterpenes, alisol B 23-acetate (1a), alisol C 23-acetate (2a), alisol B (3a), and alisol A 24-acetate (4a), were isolated from the rhizome of Alismatis plantago-aquatica L. var. orientale Samuelson (Alismataceae) and eleven protostane derivatives (compounds 1-11) were obtained by selective modification from alisol B 23-acetate (1a). These compounds were investigated for their anti-complement activity against the classical pathway of the complement system. Alisol B (3a) and alisol A 24-acetate (4a) exhibited anti-complement activity with IC50 values of 150 and 130 μM. Among the synthetic derivatives, the tetrahydroxylated protostane triterpene (9) showed moderate inhibitory activity with IC50 value of 97.1 μM. Introduction of an aldehyde group at C-23 (10; IC50 value, 47.7 μM) showed the most potent inhibitory effect on the complement system in vitro.-
dc.publisherPharmaceutical Soc Korea-
dc.titleAnti-complementary activity of protostane-type triterpenes from Alismatis rhizoma-
dc.title.alternativeAnti-complementary activity of protostane-type triterpenes from Alismatis rhizoma-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number6-
dc.citation.endPage465-
dc.citation.startPage463-
dc.citation.volume26-
dc.contributor.affiliatedAuthorSang Myung Lee-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorRen Bo An-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.affiliatedAuthorHyouk Joung-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName이상명-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeName안인파-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName정혁-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 26, no. 6, pp. 463-465-
dc.identifier.doi10.1007/bf02976863-
dc.subject.keywordAlismatis rhizoma-
dc.subject.keywordAnti-complementary activity-
dc.subject.keywordProtostane-type triterpene-
dc.subject.localAlismatis Rhizoma-
dc.subject.localalismatis rhizoma-
dc.subject.localAlismatis rhizoma-
dc.subject.localanticomplementary actvity-
dc.subject.localAnticomplementary activity-
dc.subject.localAnti-complementary activity-
dc.subject.localanti-complementary activity-
dc.subject.localanticomplementary activity-
dc.subject.localProtostane-type triterpene-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.