Anti-complement activity of constituents from the stem-bark of Juglans mandshurica

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Anti-complement activity of constituents from the stem-bark of Juglans mandshurica
Byung Sun Min; Sun Young Lee; Jung Hee Kim; Joong Ku Lee; Tae Jin Kim; D H Kim; Y H Kim; Hyouk Joung; Hyeong Kyu Lee; N Nakamura; H Miyashiro; M Hattori
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 26, no. 7, pp. 1042-1044
Publication Year
Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-tetragalloylglucose (6), were evaluated for their anti-complement activity against complement system. Afzelin (2) and quercitrin (3) showed inhibitory activity against complement system with 50% inhibitory concentrations (IC50) values of 258 and 440 μM. 1,2,6-Trigalloylglucose (5) and 1,2,3,6-tetragalloylglucose (6) exhibited anti-complement activity with IC 50 values of 136 and 34 μM. In terms of the evaluation of the structure-activity relationship of 3,5,7-trihydroxyflavone, compounds 2, 3, and 4 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (4a) as their aglycones, and these were also tested for their anti-complement activity. of the three aglycones, kaempferol (2a) exhibited weak anti-complement activity with an IC50 value of 730 μM, while quercetin (3a) and myricetin (4a) were inactive in this assay system. Among the compounds tested, 1,2,3,6-tetragalloylglucose (6) showed the most potent anticomplement activity (IC50, 34 μM).
1,2,3,6-tetragalloylglucose1,2,6-trigalloylglucose3,5,7-trihydroxyflavoneAnti-complement activityJuglans mandshurica
Pharmaceutical Soc Japan
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Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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