Neuroprotective activity of p-Terphenyl leucomentins from the mushroom Paxillus panuoides

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Title
Neuroprotective activity of p-Terphenyl leucomentins from the mushroom Paxillus panuoides
Author(s)
In Kyoung Lee; Bong Sik Yun; Jong Pyung KimIn Ja Ryoo; Y H Kim; Ick Dong Yoo
Bibliographic Citation
Bioscience Biotechnology and Biochemistry, vol. 67, no. 8, pp. 1813-1816
Publication Year
2003
Abstract
The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H 2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.
Keyword
Glutamate neurotoxicityIron chelatorLeu-comentinsMushroomPaxillus panuoides
ISSN
0916-8451
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1271/bbb.67.1813
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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