α-Lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways

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dc.contributor.authorKyung Joo Cho-
dc.contributor.authorHae Eun Moon-
dc.contributor.authorH Moini-
dc.contributor.authorL Packer-
dc.contributor.authorDo Young Yoon-
dc.contributor.authorA S Chung-
dc.date.accessioned2017-04-19T09:00:17Z-
dc.date.available2017-04-19T09:00:17Z-
dc.date.issued2003-
dc.identifier.issn00219258-
dc.identifier.uri10.1074/jbc.M210747200ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6241-
dc.description.abstractObesity is associated with a number of pathological disorders such as non-insulin-dependent diabetes, hypertension, hyperlipidemia, and cardiovascular diseases. α-Lipoic acid (LA) has been demonstrated to activate the insulin signaling pathway and to exert insulin-like actions in adipose and muscle cells. Based on this similarity LA is expected to promote adipogenesis in pre-adipocytes. Here, however, we report that LA inhibited differentiation of 3T3-L1 pre-adipocytes induced by a hormonal mixture or troglitazone. Northern blot analysis of cells demonstrated that this inhibition was accompanied with attenuated expression of adipocyte-specific fatty acid-binding protein and lipoprotein lipase. Electrophoretic mobility shift assay and Western blot analysis of cells demonstrated that LA modulates transcriptional activity and/or expression of a set of anti- or pro-adipogenic transcription factors. LA treatment of 3T3-L1 pre-adipocytes also resulted in prolonged activation of major mitogen-activated protein kinase signaling pathways but showed little or no effect on the activity of the insulin receptor/Akt signaling pathway. These findings suggest that LA inhibits insulin or the hormonal mixture-induced differentiation of 3T3-L1 pre-adipocytes by modulating activity and/or expression of pro- or anti-adipogenic transcription factors mainly through activating the MAPK pathways.-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleα-Lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways-
dc.title.alternativeα-Lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways-
dc.typeArticle-
dc.citation.titleJournal of Biological Chemistry-
dc.citation.number37-
dc.citation.endPage34833-
dc.citation.startPage34823-
dc.citation.volume278-
dc.contributor.alternativeName조경주-
dc.contributor.alternativeName문해은-
dc.contributor.alternativeNameMoini-
dc.contributor.alternativeNamePacker-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName정안식-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, vol. 278, no. 37, pp. 34823-34833-
dc.identifier.doi10.1074/jbc.M210747200-
dc.description.journalClassY-
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