ent-Kaurane diterpenoids from croton tonkinensis inhibit LPS-induced NF-κB activation and NO production

Cited 51 time in scopus
Metadata Downloads
Title
ent-Kaurane diterpenoids from croton tonkinensis inhibit LPS-induced NF-κB activation and NO production
Author(s)
P M Giang; H Z Jin; P T Son; Jeong-Hyung Lee; Young-Soo Hong; Jung Joon Lee
Bibliographic Citation
Journal of Natural Products, vol. 66, no. 9, pp. 1217-1220
Publication Year
2003
Abstract
Four ent-kaurane diterpenoids including two known, ent-7α,14β -dihydroxykaur-16-en-15-one (1) and ent-18-acetoxy-7α -hydroxykaur-16-en-5-one (2), and two new, ent-1β-acetoxy-7α,14β -dihydroxykaur-16-en-15-one (3) and ent-18-acetoxy-7α,14β -dihydroxykaur-16-en-15-one (4), were isolated from the leaves of Croton tonkinensis in a search for inhibitors of NF-κB activation and nitric oxide production. These ent-kauranoids inhibited LPS-induced NF-κB activation in murine macrophage RAW264.7 cells at IC50 values between 0.07 and 0.42 μM. Consistently, the ent-kauranoids markedly reduced LPS-induced NO production in a comparable concentration-dependent manner.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np030139y
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.