Pirfenidone suppressed the development of glomerulosclerosis in the FGS/Kist mouse

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Title
Pirfenidone suppressed the development of glomerulosclerosis in the FGS/Kist mouse
Author(s)
H S Park; L Bao; Y J Kim; I H Cho; Chul Ho Lee; Byung Hwa Hyun; S B Margolin; Y H Park
Bibliographic Citation
Journal of Korean Medical Science, vol. 18, no. 4, pp. 527-533
Publication Year
2003
Abstract
Pirfenidone (PFD) is a newly developed anti-fibrotic agent. We evaluated the effect of PFD for the prevention of renal fibrosis using a spontaneous progressive glomerulosclerosis animal model, FGS/Kist mice. Male and female FGS/Kist mice were fed a diet containing 0.5% PFD or the same control diet (CD) without PFD, for 1, 2, or 3-month periods. Body weight was monitored for the general effect of PFD on the mice. Proteinuria and glomerular filtration rate (GFR) were evaluated for renal function. The sclerosis index was examined for the morphological changes. There were no significant changes in body weight between the PFD and control groups in both sexes. Proteinuria levels were low in all the PFD groups compared to the corresponding CD groups. The sclerosis scores were also reduced in both sexes of the 3-month PFD groups (p<0.05), and glomerular filtration rates were increased in both sexes of the 3-month PFD groups compared to the CD groups. The treatment of PFD for 1 or 2-month periods did not have statistic significances but the treatment for 3 months had statistic significances in sclerosis and GFR compared to CD groups. These results suggested that long-term administration of PFD suppressed the progression of glomerulosclerosis and improved renal function of the FGS/Kist mice.
Keyword
AnimalDisease modelsFibrosisGlomerular filtration rateGlomerulosclerosis, focalPirfenidone
ISSN
1011-8934
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3346/jkms.2003.18.4.527
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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