Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa

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Title
Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa
Author(s)
Seung Ho Lee; Mi Young Lee; Hyun Mi Kang; Dong Cho HanKwang Hee Son; D C Yang; N D Sung; Chang Woo Lee; Hwan Mook Kim; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 11, no. 21, pp. 4545-4549
Publication Year
2003
Abstract
Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmc.2003.08.008
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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