Open Access@KRIBBDivision of A.I. & Biomedical ResearchGenomic Medicine Research Center1. Journal Articles
Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa
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- Title
- Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa
- Author(s)
- Seung Ho Lee; Mi Young Lee; Hyun Mi Kang; Dong Cho Han; Kwang Hee Son; D C Yang; N D Sung; Chang Woo Lee; Hwan Mook Kim; Byoung-Mog Kwon
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry, vol. 11, no. 21, pp. 4545-4549
- Publication Year
- 2003
- Abstract
- Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.
- ISSN
- 0968-0896
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmc.2003.08.008
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Genomic Medicine Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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