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- Title
- Expression of endoplasmic reticulum chaperone ERp29 in the injured spinal cord
- Author(s)
- S J Park; H M Hwang; Y H Lee; K H You; Kee Sun Shin; O Y Kwon
- Bibliographic Citation
- Korean Journal of Biological Sciences, vol. 7, pp. 265-269
- Publication Year
- 2003
- Abstract
- Regulation of endoplasmic reticulum (ER) chaperone, ERp29, in traumatized rat spinal cord was investigated. Compared to the control, ERp29 expression was down-regulated at the lesion site 1 d after spinal cord injury. However, ERp29 expression gradually increased from 3 d after the injury and peaked remarkably after 7 d. Two ER chaperones (GRP94 and BiP) showed constantly strong expression levels 1 d after spinal cord injury while the expression levels of the other two (calnexin and PDI) were unchanged. In the case of ERp72, its expression level was increased 1 d after the injury and gradually decreased thereafter. This study suggests that ERp29 expression in the spinal cord after traumatic injury might be associated with the posttraumatic neural survival, playing a role as a molecular chaperone.
- Keyword
- ERp29endoplasmic reticulumchaperonespinal cord injury
- ISSN
- 1226-5071
- Publisher
- Korea Soc-Assoc-Inst
- DOI
- http://dx.doi.org/10.1080/12265071.2003.9647714
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
- Files in This Item:
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