Expression of endoplasmic reticulum chaperone ERp29 in the injured spinal cord

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Title
Expression of endoplasmic reticulum chaperone ERp29 in the injured spinal cord
Author(s)
S J Park; H M Hwang; Y H Lee; K H You; Kee Sun Shin; O Y Kwon
Bibliographic Citation
Korean Journal of Biological Sciences, vol. 7, pp. 265-269
Publication Year
2003
Abstract
Regulation of endoplasmic reticulum (ER) chaperone, ERp29, in traumatized rat spinal cord was investigated. Compared to the control, ERp29 expression was down-regulated at the lesion site 1 d after spinal cord injury. However, ERp29 expression gradually increased from 3 d after the injury and peaked remarkably after 7 d. Two ER chaperones (GRP94 and BiP) showed constantly strong expression levels 1 d after spinal cord injury while the expression levels of the other two (calnexin and PDI) were unchanged. In the case of ERp72, its expression level was increased 1 d after the injury and gradually decreased thereafter. This study suggests that ERp29 expression in the spinal cord after traumatic injury might be associated with the posttraumatic neural survival, playing a role as a molecular chaperone.
Keyword
ERp29endoplasmic reticulumchaperonespinal cord injury
ISSN
1226-5071
Publisher
South Korea
DOI
http://dx.doi.org/10.1080/12265071.2003.9647714
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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