DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang Kyu Choi | - |
dc.contributor.author | B I Yoon | - |
dc.contributor.author | Young Suk Won | - |
dc.contributor.author | Chul Ho Lee | - |
dc.contributor.author | Byung Hwa Hyun | - |
dc.contributor.author | Hyoung-Chin Kim | - |
dc.contributor.author | Goo Taeg Oh | - |
dc.contributor.author | D Y Kim | - |
dc.date.accessioned | 2017-04-19T09:00:22Z | - |
dc.date.available | 2017-04-19T09:00:22Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0932-0113 | - |
dc.identifier.uri | 10.1007/s00436-003-0934-2 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6259 | - |
dc.description.abstract | FVB and BALB/c mice show different morbidity, development of Clonorchis sinensis, and pathological changes following C. sinensis infection. FVB mice are susceptible and BALB/c mice are relatively more resistant to C. sinensis infection. To investigate the relationship between cytokine reaction and susceptibility to C. sinensis infection in FVB and BALB/c mice, we described both the patterns and kinetics of Th1 cytokines and Th2 cytokines in spleen cell culture. Interleukin (IL)-4 and IL-10 cytokine production in the culture supernatants of the concanavalin-A-stimulated spleen cells increased at 2-3 weeks post-infection in both strains. IL-5 production increased between 2 and 5 weeks post-infection in both strains, and reached a peak level at 2 weeks post-infection in BALB/c mice and 4 weeks post-infection in FVB mice. In contrast, gamma interferon (IFN-γ) production decreased between 2 and 4 weeks in both strains. IL-2 production increased slightly in BALB/c mice following infection, but was unchanged in FVB mice. IL-4 production over preinfection levels was significantly higher in FVB mice, whereas IFN-γ, IL-2, and IL-10 production were significantly higher in BALB/c mice. The levels of serum immunoglobulin E (IgE) and blood eosinophils in both mouse strains significantly increased between 3 and 6 weeks postinfection. Serum IgE levels were significantly higher in FVB mice than in BALB/c mice. The results of this study suggest that susceptibility to C. sinensis infection is associated with Th2 cytokine production, especially IL-4 which is predominant in relatively susceptible FVB mice. | - |
dc.publisher | Springer | - |
dc.title | Cytokine responses in mice infected with Clonorchis sinensis | - |
dc.title.alternative | Cytokine responses in mice infected with Clonorchis sinensis | - |
dc.type | Article | - |
dc.citation.title | Parasitology Research | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 93 | - |
dc.citation.startPage | 87 | - |
dc.citation.volume | 91 | - |
dc.contributor.affiliatedAuthor | Yang Kyu Choi | - |
dc.contributor.affiliatedAuthor | Young Suk Won | - |
dc.contributor.affiliatedAuthor | Chul Ho Lee | - |
dc.contributor.affiliatedAuthor | Byung Hwa Hyun | - |
dc.contributor.affiliatedAuthor | Hyoung-Chin Kim | - |
dc.contributor.affiliatedAuthor | Goo Taeg Oh | - |
dc.contributor.alternativeName | 최양규 | - |
dc.contributor.alternativeName | 윤병일 | - |
dc.contributor.alternativeName | 원영석 | - |
dc.contributor.alternativeName | 이철호 | - |
dc.contributor.alternativeName | 현병화 | - |
dc.contributor.alternativeName | 김형진 | - |
dc.contributor.alternativeName | 오구택 | - |
dc.contributor.alternativeName | 김대용 | - |
dc.identifier.bibliographicCitation | Parasitology Research, vol. 91, no. 2, pp. 87-93 | - |
dc.identifier.doi | 10.1007/s00436-003-0934-2 | - |
dc.description.journalClass | Y | - |
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