Caspase-3-dependent apoptosis in vascular smooth muscle cell by proteasome inhibition

Cited 8 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorS C Kim-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorYoung Kook Kim-
dc.contributor.authorKoanhoi Kim-
dc.date.accessioned2017-04-19T09:00:24Z-
dc.date.available2017-04-19T09:00:24Z-
dc.date.issued2003-
dc.identifier.issn01602446-
dc.identifier.uri10.1097/00005344-200310000-00014ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6272-
dc.description.abstractThe effects of a number of substances on neointima formation following angioplasty have been investigated in animal models. It was suggested that delivering of proteasome inhibitor to the site of vascular injury would be a potential therapeutic approach in prevention of vascular restenosis. But the mechanisms underlying biologic activities of proteasome inhibition in vascular smooth muscle cells (VSMCs) are largely unknown. We have investigated effects of proteasome inhibition on VSMCs using proteasome inhibitor MG115. MG115 induced apoptotic death in VSMCs as determined by viability, morphology, and DNA fragmentation. Proteasome inhibition was accompanied by up-regulation of p53, p21, and p27. In contrast, there were no appreciable alterations in the levels of Bcl-2 and Bax. Proteasome inhibition was followed by activation of caspase-3 but not of -8. The induction of apoptosis was suppressed by treatment with a selective inhibitor of the caspase-3 family, z-DEVD-fmk but not by N G-monomethyl-L-arginine. These results indicate that proteasome inhibition induces apoptosis in VSMCs by activation of caspase-3.-
dc.publisherKluwer-
dc.titleCaspase-3-dependent apoptosis in vascular smooth muscle cell by proteasome inhibition-
dc.title.alternativeCaspase-3-dependent apoptosis in vascular smooth muscle cell by proteasome inhibition-
dc.typeArticle-
dc.citation.titleJournal of Cardiovascular Pharmacology-
dc.citation.number4-
dc.citation.endPage560-
dc.citation.startPage554-
dc.citation.volume42-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeName김선춘-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName김영국-
dc.contributor.alternativeName김관회-
dc.identifier.bibliographicCitationJournal of Cardiovascular Pharmacology, vol. 42, no. 4, pp. 554-560-
dc.identifier.doi10.1097/00005344-200310000-00014-
dc.subject.keywordApoptosis-
dc.subject.keywordP53-
dc.subject.keywordProteasome-
dc.subject.keywordRestenosis-
dc.subject.keywordSmooth muscle cell-
dc.subject.localApoptosis-
dc.subject.localP53-
dc.subject.localp53-
dc.subject.localProteasome-
dc.subject.localRestenosis-
dc.subject.localSmooth muscle cell-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.