The absolute configuration of prunioside A from Spiraea prunifolia and biological activities of related compounds

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Title
The absolute configuration of prunioside A from Spiraea prunifolia and biological activities of related compounds
Author(s)
Hyun Cheol Oh; H S Shin; G S Oh; H O Pae; K Y Chai; H T Chung; H S Lee
Bibliographic Citation
Phytochemistry, vol. 64, no. 6, pp. 1113-1118
Publication Year
2003
Abstract
The stereochemistry of prunioside A isolated from Spiraea prunifolia was determined by chemical transformations and NMR spectral data analysis, The configurations at C-5 and C-6 were determined to be 5S and 6R by application of the modified Mosher's method, CD analysis, and 13C NMR spectroscopic data analysis of an acetonide derivative. Other compounds related to prunioside A have inhibitory effects on the synthesis of nitric oxide in LPS-stimulated macrophage-like RAW 264.7 cells.
Keyword
inhibitory effects on nitric oxide (NO) productionmosher's methodprunioside Arosaceaespiraea prunifolia
ISSN
0031-9422
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0031-9422(03)00499-0
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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