Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

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dc.contributor.authorH J Jung-
dc.contributor.authorHyang Burm Lee-
dc.contributor.authorC H Lim-
dc.contributor.authorChang-Jin Kim-
dc.contributor.authorH J Kwon-
dc.date.accessioned2017-04-19T09:00:27Z-
dc.date.available2017-04-19T09:00:27Z-
dc.date.issued2003-
dc.identifier.issn0968-0896-
dc.identifier.uri10.1016/S0968-0896(03)00523-6ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6293-
dc.description.abstractCochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.-
dc.publisherElsevier-
dc.titleCochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola-
dc.title.alternativeCochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number22-
dc.citation.endPage4747-
dc.citation.startPage4743-
dc.citation.volume11-
dc.contributor.affiliatedAuthorHyang Burm Lee-
dc.contributor.affiliatedAuthorChang-Jin Kim-
dc.contributor.alternativeName정혜진-
dc.contributor.alternativeName이향범-
dc.contributor.alternativeName임치환-
dc.contributor.alternativeName김창진-
dc.contributor.alternativeName권호정-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 11, no. 22, pp. 4743-4747-
dc.identifier.doi10.1016/S0968-0896(03)00523-6-
dc.description.journalClassY-
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