Inhibitory effects of Bombusae concretio salicea on neuronal secretion of alzheimer's β-amyloid peptides, a neurodegenerative peptide

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Title
Inhibitory effects of Bombusae concretio salicea on neuronal secretion of alzheimer's β-amyloid peptides, a neurodegenerative peptide
Author(s)
J C Jeong; S K Kang; C H Yoon; Y J Seo; C W Hwang; Jeong Heon Ko; Y C Lee; Y C Chang; C H Kim
Bibliographic Citation
Neurochemical Research, vol. 28, no. 12, pp. 1785-1792
Publication Year
2003
Abstract
Alzheimer's disease (AD) is characterized by the age-related deposition of β-amyloid (Aβ) 40/42 peptide aggregates in vulnerable brain regions. Multiple levels of evidence implicate a central role for Aβ in the pathophysiology of AD. Aβ is generated by the regulated cleavage of a = 700 amino acid Aβ precursor protein (βAPP). Full-length βAPP can undergo proteolytic cleavage either within the Aβ domain to generate secreted sβAPPα or at the N-terminal and C-terminal domain(s) of Aβ to generate amyloidogenic Aβ peptides. Several epidemiological studies have reported that estrogen replacement therapy protects against the development of AD in postmenopausal women. The aim of this study was to elucidate the antioxidant neuroprotective mechanism of Bombusae concretio Salicea (BC). BC was effective protectants against oxidative glutamate toxicity in the murine neuroblastoma cells (N2a) and human neuroblastoma cells (SK-N-MC). BC exhibited similar protective properties against oxidative glutamate toxicity and H2O2 toxicity. BC exhibited an antioxidant activity at approximately 20 μg/ml. BC of 5 μg/ml was ineffective in preventing the oxidative modification of LDL. The half-maximal effective concentration for BC was 16 μg/ml. These results suggested that BC supplementation in elderly men may be protective in the treatment of Alzheimer's disease (AD). We report here that treatment with BC increases the secretion of the nonamyloidogenic APP fragment, sβAPPα and decreases the secretion of Aβ peptides from N2a cells and rat primary cerebrocortical neurons. These results raise the possibility that BC supplementation in elderly men may be protective in the treatment of AD.
Keyword
β-amyloid (Aβ) 40/42 peptide aggregatesAβ precursor protein (βAPP)Alzheimer's disease (AD)Bombusae concretio SaliceaKorean herbal medicineN2aRat primary cerebrocortical neurons
ISSN
0364-3190
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1026155321328
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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