Fine mapping of the circling(cir) gene on the distal portion of mouse chromosome 9

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dc.contributor.authorK I Cho-
dc.contributor.authorJeong Woong Lee-
dc.contributor.authorK S Kim-
dc.contributor.authorE J Lee-
dc.contributor.authorJ G Suh-
dc.contributor.authorH J Lee-
dc.contributor.authorH T Kim-
dc.contributor.authorS H Hong-
dc.contributor.authorW H Chung-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorByung Hwa Hyun-
dc.contributor.authorY S Oh-
dc.contributor.authorZ Y Ryoo-
dc.date.accessioned2017-04-19T09:00:28Z-
dc.date.available2017-04-19T09:00:28Z-
dc.date.issued2003-
dc.identifier.issn1532-0820-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6297-
dc.description.abstractCircling mice manifest profound deafness, head-tossing, and bi-directional circling behavior, which they inherit in autosomal recessive manner. Histologic examination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. A genetic linkage map was constructed for an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mit116/D9Mit15 and D9Mit38 on mouse chromosome (Chr) 9. Estimated distances between cir and D9Mit116, and between cir and D9Mit38 were 0.70 ± 0.40 and 0.23 ± 0.23 cM, respectively. Order of the markers was defined as follows: centromere - D9Mit182 - D9Mit51/D9Mit79/D9Mit310 -D9Mit212/D9Mit184 - D9Mit116/D9Mit15 - cir - D9Mit38 - D9Mit20 - D9Mit243 - D9Mit16 - D9Mit55/D9Mit125 - D9Mit281. On the basis of genetic mapping, we constructed a yeast artificial chromosome (YAC) contig across the cir region. The cir gene is located between the lactotransferrin (ltf) and microtubule-associated protein (map4) genes. The distal portion of mouse Chr 9 encompassing the cir region is homologous with human chromosome 3p21, which contains the Deafness, form B: Autosomal Recessive Deafness (DFNB6) locus. Therefore, the circling mouse is a potential animal model for DFNB6 deafness in humans.-
dc.publisherAmer Assoc Laboratory Animal Science-
dc.titleFine mapping of the circling(cir) gene on the distal portion of mouse chromosome 9-
dc.title.alternativeFine mapping of the circling(cir) gene on the distal portion of mouse chromosome 9-
dc.typeArticle-
dc.citation.titleComparative Medicine-
dc.citation.number6-
dc.citation.endPage648-
dc.citation.startPage642-
dc.citation.volume53-
dc.contributor.affiliatedAuthorJeong Woong Lee-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.contributor.alternativeName조경인-
dc.contributor.alternativeName이정웅-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName이은주-
dc.contributor.alternativeName서준교-
dc.contributor.alternativeName이호준-
dc.contributor.alternativeName김현택-
dc.contributor.alternativeName홍성화-
dc.contributor.alternativeName정원호-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName현병화-
dc.contributor.alternativeName오양석-
dc.contributor.alternativeName류재영-
dc.identifier.bibliographicCitationComparative Medicine, vol. 53, no. 6, pp. 642-648-
dc.description.journalClassY-
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Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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