Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells

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Title
Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells
Author(s)
X F Cai; G Shen; N T Dat; O H Kang; Young Mi Lee; Jung Joon Lee; Y H Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 26, no. 9, pp. 731-734
Publication Year
2003
Abstract
Five known kaurane type diterpenoids, 16α H,17-isovaleryloxy- ent-kauran-19-oic acid (1), 16α-hydroxy-17-isovaleryloxy- ent-kauran-19-oic acid (2), paniculoside-IV (3), 16α-hydroxy- ent-kauran-19-oic acid (4), and ent-kaur-16-en-19-oic acid (5) were isolated from the root of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. The structures of these compounds were established from physicochemical and spectral data. Among the isolated compounds 16α H,17-isovaleryloxy- ent-kauran-19-oic acid (1) showed potent inhibitory activity (IC50 value, 16.2 uM) on TNF-α secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line.
Keyword
acanthopanax koreanuminhibitory effectkaurane type diterpenoidTNF-α secretion
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/bf02976683
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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