Scale-up of recombinant hirudin production from Saccharomyces cerevisiae

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dc.contributor.authorChul Ho Kim-
dc.contributor.authorK J Rao-
dc.contributor.authorD J Youn-
dc.contributor.authorSang Ki Rhee-
dc.date.accessioned2017-04-19T09:00:30Z-
dc.date.available2017-04-19T09:00:30Z-
dc.date.issued2003-
dc.identifier.issn12268372-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6305-
dc.description.abstractScale-up of hirudin production from Saccharomyces cerevisiae from bench-scale to pilot-scale was carried out based on constant volumetric oxygen transfer coefficient (KLa). Fed-batch mode of cultivation using step-wise feeding strategy of galactose was employed for the production of hirudin in a 30-L and a 300-L pilot-scale fermentor. The final hirudin concentrations were achieved 390 mg/L and 286.1 mg/L, and the volumetric productivities were 80.4% and 90.7% with the 30-L and 300-L fermentors, respectively, compared to the productivity of the 5-L bench-scale fermentor.-
dc.publisherSouth Korea-
dc.titleScale-up of recombinant hirudin production from Saccharomyces cerevisiae-
dc.title.alternativeScale-up of recombinant hirudin production from Saccharomyces cerevisiae-
dc.typeArticle-
dc.citation.titleBiotechnology and Bioprocess Engineering-
dc.citation.number5-
dc.citation.endPage305-
dc.citation.startPage303-
dc.citation.volume8-
dc.contributor.affiliatedAuthorChul Ho Kim-
dc.contributor.alternativeName김철호-
dc.contributor.alternativeNameRao-
dc.contributor.alternativeName윤덕중-
dc.contributor.alternativeName이상기-
dc.identifier.bibliographicCitationBiotechnology and Bioprocess Engineering, vol. 8, no. 5, pp. 303-305-
dc.identifier.doi10.1007/BF02949222-
dc.subject.keywordfed batch fermentation-
dc.subject.keywordGAL promoter-
dc.subject.keywordrecombinant hirudin-
dc.subject.keywordsaccharomyces cerevisiae-
dc.subject.keywordscale-up-
dc.subject.localfed batch fermentation-
dc.subject.localGAL promoter-
dc.subject.localrecombinant hirudin-
dc.subject.localRecombinant hirudin-
dc.subject.localsaccharomyces cerevisiae-
dc.subject.localSaccharomyces cerevisiae-
dc.subject.localscale-up-
dc.subject.localScale-up-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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