Cooperative transformation of murine fibroblast NIH3T3 cells by hepatitis C virus core protein and hepatitis B virus X protein

Cited 8 time in scopus
Metadata Downloads
Title
Cooperative transformation of murine fibroblast NIH3T3 cells by hepatitis C virus core protein and hepatitis B virus X protein
Author(s)
E Y Jung; H K Kang; J Chang; Dae Yeul Yu; K L Jang
Bibliographic Citation
Virus Research, vol. 94, no. 2, pp. 79-84
Publication Year
2003
Abstract
Co-infection with hepatitis B virus (HBV) and hepatitis C Virus (HCV) is associated with increased frequency in the development of hepatocellular carcinoma (HCC). Here, we demonstrated that HBV X protein (HBx) and HCV core cooperate to transform mouse fibroblast NIH3T3 cells. They additively stimulated cell growth, especially in the absence of serum growth factors. In addition, co-expression of HBx and HCV core had additive effects on the induction of anchorage-independent cell growth as well as on the secretion of matrix metalloproteases, which may contribute to increased metastatic potential. Furthermore, the cells expressing both viral proteins exhibited higher tumorigenicity, as demonstrated in athymic nude mice.
Keyword
Cell transformationCoreHBVHBxHCVHepatocellular carcinoma
ISSN
0168-1702
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0168-1702(03)00135-7
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.