Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties

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dc.contributor.authorJong Pyung Kim-
dc.contributor.authorByoung Kwon Kim-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorChoong Hwan Lee-
dc.contributor.authorIn Kyung Lee-
dc.contributor.authorWon Gon Kim-
dc.contributor.authorSangku Lee-
dc.contributor.authorY R Pyun-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T09:00:40Z-
dc.date.available2017-04-19T09:00:40Z-
dc.date.issued2003-
dc.identifier.issn00218820-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6359-
dc.description.abstractNew melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nm and MIC value of 0.9 μM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.-
dc.publisherSpringer-Nature Pub Group-
dc.titleMelanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties-
dc.title.alternativeMelanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number12-
dc.citation.endPage999-
dc.citation.startPage993-
dc.citation.volume56-
dc.contributor.affiliatedAuthorJong Pyung Kim-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.alternativeName김종평-
dc.contributor.alternativeName김병권-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName이충환-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName변유량-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 56, no. 12, pp. 993-999-
dc.identifier.doi10.7164/antibiotics.56.993-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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