DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | Y J Jeon | - |
dc.contributor.author | J H Suh | - |
dc.contributor.author | Song Kyu Park | - |
dc.contributor.author | Kyu-Hwan Yang | - |
dc.contributor.author | Hwan Mook Kim | - |
dc.date.accessioned | 2017-04-19T09:00:42Z | - |
dc.date.available | 2017-04-19T09:00:42Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | 10.1016/j.canlet.2003.08.014 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6372 | - |
dc.description.abstract | In the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1β (IL-1β) gene expression in lipopolysaccharide (LPS)-stimulated macrophages. Acetylaminofluorene inhibited IL-1 production in LPS-stimulated splenic macrophages and RAW 264.7 cells. Additionally, AAF also suppressed LPS-induced mRNA expression of IL-1β in macrophages. To further characterize the molecular mechanism responsible for AAF-mediated suppression of IL-1β, we investigated the effect of AAF on LPS-mediated activation of transcription factors, such as NF-κB, AP-1, CRE and NF-IL6, which are known to be important for LPS-induced gene expression of IL-1β. Treatment of AAF caused a dose-related inhibition of LPS-induced NF-κB/Rel transcriptional activation, while the transcriptional activation of AP-1, CRE and NF-IL6 was not affected by AAF. Furthermore, LPS-induced NF-κB/Rel DNA binding was also suppressed by AAF treatment. These results suggest that AAF inhibits IL-1β gene expression by blocking NF-κB/Rel activation. | - |
dc.publisher | Elsevier | - |
dc.title | 2-Acetylaminofluorene inhibits interleukin-1β production in LPS-stimulated macrophages by blocking NF-κB/Rel activation | - |
dc.title.alternative | 2-Acetylaminofluorene inhibits interleukin-1β production in LPS-stimulated macrophages by blocking NF-κB/Rel activation | - |
dc.type | Article | - |
dc.citation.title | Cancer Letters | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 98 | - |
dc.citation.startPage | 91 | - |
dc.citation.volume | 203 | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.affiliatedAuthor | Song Kyu Park | - |
dc.contributor.affiliatedAuthor | Kyu-Hwan Yang | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 전영진 | - |
dc.contributor.alternativeName | 서재홍 | - |
dc.contributor.alternativeName | 박성규 | - |
dc.contributor.alternativeName | 양규환 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.identifier.bibliographicCitation | Cancer Letters, vol. 203, no. 1, pp. 91-98 | - |
dc.identifier.doi | 10.1016/j.canlet.2003.08.014 | - |
dc.subject.keyword | 2-Acetylaminofluorene | - |
dc.subject.keyword | interleukin-1β | - |
dc.subject.keyword | NF-κB/Rel | - |
dc.subject.local | 2-acetylaminofluorene (2-AAF) | - |
dc.subject.local | 2-acetlyaminofluorene (2-AAF) | - |
dc.subject.local | 2-acetylaminofluorene | - |
dc.subject.local | 2-Acetylaminofluorene | - |
dc.subject.local | Interleukin-1β | - |
dc.subject.local | Interleukin-1beta | - |
dc.subject.local | interleukin-1β | - |
dc.subject.local | NF-κB/Rel | - |
dc.description.journalClass | Y | - |
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