2-Acetylaminofluorene inhibits interleukin-1β production in LPS-stimulated macrophages by blocking NF-κB/Rel activation

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dc.contributor.authorJong Soon Kang-
dc.contributor.authorY J Jeon-
dc.contributor.authorJ H Suh-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorKyu-Hwan Yang-
dc.contributor.authorHwan Mook Kim-
dc.date.accessioned2017-04-19T09:00:42Z-
dc.date.available2017-04-19T09:00:42Z-
dc.date.issued2004-
dc.identifier.issn0304-3835-
dc.identifier.uri10.1016/j.canlet.2003.08.014ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6372-
dc.description.abstractIn the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1β (IL-1β) gene expression in lipopolysaccharide (LPS)-stimulated macrophages. Acetylaminofluorene inhibited IL-1 production in LPS-stimulated splenic macrophages and RAW 264.7 cells. Additionally, AAF also suppressed LPS-induced mRNA expression of IL-1β in macrophages. To further characterize the molecular mechanism responsible for AAF-mediated suppression of IL-1β, we investigated the effect of AAF on LPS-mediated activation of transcription factors, such as NF-κB, AP-1, CRE and NF-IL6, which are known to be important for LPS-induced gene expression of IL-1β. Treatment of AAF caused a dose-related inhibition of LPS-induced NF-κB/Rel transcriptional activation, while the transcriptional activation of AP-1, CRE and NF-IL6 was not affected by AAF. Furthermore, LPS-induced NF-κB/Rel DNA binding was also suppressed by AAF treatment. These results suggest that AAF inhibits IL-1β gene expression by blocking NF-κB/Rel activation.-
dc.publisherElsevier-
dc.title2-Acetylaminofluorene inhibits interleukin-1β production in LPS-stimulated macrophages by blocking NF-κB/Rel activation-
dc.title.alternative2-Acetylaminofluorene inhibits interleukin-1β production in LPS-stimulated macrophages by blocking NF-κB/Rel activation-
dc.typeArticle-
dc.citation.titleCancer Letters-
dc.citation.number1-
dc.citation.endPage98-
dc.citation.startPage91-
dc.citation.volume203-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.affiliatedAuthorSong Kyu Park-
dc.contributor.affiliatedAuthorKyu-Hwan Yang-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName전영진-
dc.contributor.alternativeName서재홍-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName양규환-
dc.contributor.alternativeName김환묵-
dc.identifier.bibliographicCitationCancer Letters, vol. 203, no. 1, pp. 91-98-
dc.identifier.doi10.1016/j.canlet.2003.08.014-
dc.subject.keyword2-Acetylaminofluorene-
dc.subject.keywordinterleukin-1β-
dc.subject.keywordNF-κB/Rel-
dc.subject.local2-acetylaminofluorene (2-AAF)-
dc.subject.local2-acetlyaminofluorene (2-AAF)-
dc.subject.local2-acetylaminofluorene-
dc.subject.local2-Acetylaminofluorene-
dc.subject.localInterleukin-1β-
dc.subject.localInterleukin-1beta-
dc.subject.localinterleukin-1β-
dc.subject.localNF-κB/Rel-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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