LAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast

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dc.contributor.authorY D Park-
dc.contributor.authorW H Kang-
dc.contributor.authorW S Yang-
dc.contributor.authorK S Shin-
dc.contributor.authorKyung Sook Bae-
dc.contributor.authorH M Park-
dc.date.accessioned2017-04-19T09:00:43Z-
dc.date.available2017-04-19T09:00:43Z-
dc.date.issued2003-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2003.10.110ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6379-
dc.description.abstractPreviously, we reported that the LAMMER kinase homolog, Lkh1, is a negative regulator of filamentous growth and asexual flocculation in the fission yeast, Schizosaccharomyces pombe. Here, we report that the lkh1 + null mutant is sensitive to oxidative stress because of a reduction in the expression of genes for antioxidant enzymes such as catalase (ctt1+) and Cu,Zn-superoxide dismutase (sod1+). Furthermore, the lkh1+ null mutant shows increased levels of intracellular peroxides under conditions of oxidative stress compared with wild-type cells. Interestingly, expression of the gene for the transcription factor Atf1 is reduced in the lkh1+ null mutant under oxidative stress, whereas expression of the transcription factor Pap1 is not. We report the novel finding that Lkh1 is involved in the oxidative-stress response of the fission yeast, S. pombe, and regulates the expression of antioxidant enzymes via the transcription factor Atf1.-
dc.publisherElsevier-
dc.titleLAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast-
dc.title.alternativeLAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number4-
dc.citation.endPage1083-
dc.citation.startPage1078-
dc.citation.volume311-
dc.contributor.affiliatedAuthorKyung Sook Bae-
dc.contributor.alternativeName박윤동-
dc.contributor.alternativeName강원화-
dc.contributor.alternativeName양완수-
dc.contributor.alternativeName신광수-
dc.contributor.alternativeName배경숙-
dc.contributor.alternativeName박희문-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 311, no. 4, pp. 1078-1083-
dc.identifier.doi10.1016/j.bbrc.2003.10.110-
dc.subject.keywordAtf1-
dc.subject.keywordCatalase-
dc.subject.keywordCu,Zn-superoxide dismutase-
dc.subject.keywordLAMMER kinase-
dc.subject.keywordLkh1-
dc.subject.keywordOxidative stress-
dc.subject.keywordPap1-
dc.subject.keywordSchizosaccharomyces pombe-
dc.subject.localAtf1-
dc.subject.localCatalase-
dc.subject.localcatalase-
dc.subject.localCu,Zn-superoxide dismutase-
dc.subject.localLAMMER kinase-
dc.subject.localLkh1-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.subject.localPap1-
dc.subject.localschizosaccharomyces pombe-
dc.subject.localSchizosaccharomyces pombe-
dc.subject.localSchizosacchromyces pombe-
dc.description.journalClassY-
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