Chronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver

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dc.contributor.authorH Y Ha-
dc.contributor.authorKyoung Shim Kim-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorJ K Lee-
dc.contributor.authorP L Han-
dc.date.accessioned2017-04-19T09:00:44Z-
dc.date.available2017-04-19T09:00:44Z-
dc.date.issued2003-
dc.identifier.issn03784274-
dc.identifier.uri10.1016/j.toxlet.2003.09.006ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6381-
dc.description.abstractRepeatedly delivered psychological, chemical or physical stress leads to drastic changes of physiology in various regions of body including liver. The underlying hepatic mechanisms whereby body copes with the stress conditions, however, are poorly understood. In the present study, we performed a genome-wide screen for the altered gene expression in liver of mice that were exposed to chronic restraint stress. cDNA microarray analysis followed by RT-PCR techniques led us to identify >235 genes that were up- or down-regulated by >1.8-fold in their expression levels. Among the wide ranges of genes identified from the screen, the elevated expression of a group of genes important for lipid metabolism and detoxification were particularly notable. The results of this study suggest that similar to the effects of genetically predisposed or externally-delivered environmental chemicals, diets, and drugs, the chronic restraint stress potently alters the gene expression profile in liver.-
dc.publisherElsevier-
dc.titleChronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver-
dc.title.alternativeChronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver-
dc.typeArticle-
dc.citation.titleToxicology Letters-
dc.citation.number1-
dc.citation.endPage63-
dc.citation.startPage49-
dc.citation.volume146-
dc.contributor.affiliatedAuthorKyoung Shim Kim-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName하혜영-
dc.contributor.alternativeName김경심-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName이재경-
dc.contributor.alternativeName한평림-
dc.identifier.bibliographicCitationToxicology Letters, vol. 146, no. 1, pp. 49-63-
dc.identifier.doi10.1016/j.toxlet.2003.09.006-
dc.subject.keywordCytochrome p450-
dc.subject.keywordDetoxification-
dc.subject.keywordFarnesyl transferase-
dc.subject.keywordFatty acid synthase-
dc.subject.keywordLipid metabolism-
dc.subject.keywordLiver-
dc.subject.keywordMicroarray-
dc.subject.keywordPPAR-
dc.subject.keywordRestraint stress-
dc.subject.localCytochrome p450-
dc.subject.localCytochrome P450-
dc.subject.localDetoxification-
dc.subject.localFarnesyl transferase-
dc.subject.localFatty acid synthase-
dc.subject.localFatty acid synthase (FAS)-
dc.subject.localLipid metabolism-
dc.subject.localLiver-
dc.subject.localMicroarray-
dc.subject.localPPAR-
dc.subject.localRestraint stress-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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