Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E-2 in macrophage RAW264.7 cells

Cited 20 time in scopus
Metadata Downloads
Title
Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E-2 in macrophage RAW264.7 cells
Author(s)
H J Park; R G Kim; B R Seo; J H Ha; Byung Tae Ahn; Song Hae Bok; Y S Lee; H J Kim; K T Lee
Bibliographic Citation
Planta Medica, vol. 69, no. 10, pp. 947-950
Publication Year
2003
Abstract
In the present study, we demonstrate that saucernetin-8 (1) and saucernetin-7 (2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Both compounds 1 and 2, known as dineolignans, also suppressed the expression of iNOS and COX-2 protein in a dose-dependent manner. Thus, this study suggests that compounds 1 and 2-mediated inhibition of iNOS and COX-2 expression may be one of the mechanisms responsible for the anti-inflammatory effects of the underground parts of Saururus chinensis.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2003-45106
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.