Isolation and anticomplement activity of compounds from Dendropanax morbifera

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Title
Isolation and anticomplement activity of compounds from Dendropanax morbifera
Author(s)
Bo Young Park; Byung Sun Min; Sei Ryang OhJung Hee Kim; Tae Jin Kim; D H Kim; K H Bae; Hyeong Kyu Lee
Bibliographic Citation
Journal of Ethnopharmacology, vol. 90, no. 2, pp. 403-408
Publication Year
2004
Abstract
Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrheal. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. of these, compound 1 showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98μM, whereas compounds 2-7 were inactive.
Keyword
(9Z,16S)-16-Hydroxy- 9,17-octadecadiene-12,14-diynoic acidAnticomplement activityDendropanax morbifera LeveillePolyacetylene
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jep.2003.11.002
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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