Phenotype of peroxisome proliferator-activated receptor-α(PPARα) deficient mice on mixed background fed high fat diet

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dc.contributor.authorB H Kim-
dc.contributor.authorYoung Suk Won-
dc.contributor.authorE Y Kim-
dc.contributor.authorM J Yoon-
dc.contributor.authorK T Nam-
dc.contributor.authorGoo Taeg Oh-
dc.contributor.authorD Y Kim-
dc.date.accessioned2017-04-19T09:00:46Z-
dc.date.available2017-04-19T09:00:46Z-
dc.date.issued2003-
dc.identifier.issnI0000131-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6395-
dc.description.abstractConsiderable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.-
dc.publisherSouth Korea-
dc.titlePhenotype of peroxisome proliferator-activated receptor-α(PPARα) deficient mice on mixed background fed high fat diet-
dc.title.alternativePhenotype of peroxisome proliferator-activated receptor-α(PPARα) deficient mice on mixed background fed high fat diet-
dc.typeArticle-
dc.citation.titleJournal of Veterinary Science-
dc.citation.number3-
dc.citation.endPage244-
dc.citation.startPage239-
dc.citation.volume4-
dc.contributor.affiliatedAuthorYoung Suk Won-
dc.contributor.alternativeName김방현-
dc.contributor.alternativeName원영석-
dc.contributor.alternativeName김은영-
dc.contributor.alternativeName윤미정-
dc.contributor.alternativeName남기택-
dc.contributor.alternativeName오구택-
dc.contributor.alternativeName김대용-
dc.identifier.bibliographicCitationJournal of Veterinary Science, vol. 4, no. 3, pp. 239-244-
dc.subject.keywordPhenotype-
dc.subject.keywordPPARalpha-/- mice-
dc.subject.keywordC57BL/6Nx129/Sv-
dc.subject.keywordhigh fat diet-
dc.subject.localPhenotype-
dc.subject.localPPARalpha-/- mice-
dc.subject.localC57BL/6Nx129/Sv-
dc.subject.localhigh fat diet-
dc.description.journalClassY-
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Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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