Effects of prenatal exposure to the environmental pollutant 2-bromopropane on embryo-fetal development in rats

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Title
Effects of prenatal exposure to the environmental pollutant 2-bromopropane on embryo-fetal development in rats
Author(s)
J C Kim; S H Kim; D H Shin; T H Ahn; Hyoung-Chin Kim; Y B Kim; C Z Jiang; J H Han; M K Chung
Bibliographic Citation
Toxicology, vol. 196, no. 1, pp. 77-86
Publication Year
2004
Abstract
2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones. The present study was carried out to investigate the potential adverse effects of 2-BP on pregnant dams and embryo-fetal development after maternal exposure on gestational days (GD) 6 through 19 in Sprague-Dawley rats. The test chemical was administered subcutaneously to pregnant rats at dose levels of 0, 250, 500, and 1000mg/kg per day. All dams were subjected to caesarean section on GD 20 and their fetuses were examined for external, visceral and skeletal abnormalities. In the 1000mg/kg group, maternal toxicity included an increase in the incidence of abnormal clinical signs, a suppression in the body weight and body weight gain, and a decrease in the food intake. Developmental toxicity included an increase in the fetal deaths, a decrease in the litter size, and a reduction in the fetal body weight. In addition, an increase in the incidence of fetal external, visceral, and skeletal abnormalities was seen. In the 500mg/kg group, minimal developmental toxicity including decreased fetal body weight and increased fetal ossification delay was observed. There were no adverse effects on either pregnant dams or embryo-fetal development in the 250mg/kg group. These findings suggest that a 14-day subcutaneous dose of 2-BP is embryotoxic and teratogenic at a maternally toxic dose (i.e., 1000mg/kg per day) and is minimally embryotoxic at a nonmaternally toxic dose (i.e., 500mg/kg per day) in Sprague-Dawley rats. In the present experimental conditions, the no-observed-adverse-effect level (NOAEL) of 2-BP is considered to be 500mg/kg per day for dams and 250mg/kg per day for embryo-fetal development.
Keyword
2-BromopropaneEmbryotoxicityMaternal toxicityRatsTeratogenicity
ISSN
0300-483X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.tox.2003.11.006
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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