Factors involving reprogramming in cloned embryos

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Title
Factors involving reprogramming in cloned embryos
Author(s)
N H Kim; X S Cui; I H Kim; Yong Mahn Han
Bibliographic Citation
Reproductive & Developmental Biology, vol. 27, no. 4, pp. 349-357
Publication Year
2003
Abstract
Although nuclear transfer (NT) techniques are used to clone animals, its efficiency is very low. Moreover, nuclear transfer has resulted in offspring with severe developmental problems, probably due to incomplete nuclear reprogramming. Nuclear reprogramming is characterized by functional modification of the transferred nucleus to allow it to direct normal embryo development with the potential to grow to term. Although the nature of the reprogramming factor(s) in mammals is not clear, various nuclear as well as cytoplasmic components are involved in the processes. In this article we review recent data on factors involved in the nuclear reprogramming of cloned embryos.
Keyword
Nuclear transferReprogrammingEpigenetic factorsCloned animal
ISSN
I000-0006
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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