Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice

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Title
Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice
Author(s)
K H Kim; J H Ha; S H Chung; C T Kim; S K Kim; Byung Hwa Hyun; K Sawada; Y Fukui; I K Park; G J Lee; B K Kim; N S Lee; Y G Jeong
Bibliographic Citation
Journal of Veterinary Science, vol. 4, no. 3, pp. 209-212
Publication Year
2003
Abstract
The Pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR/MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty in maintaining posture and side to side stability, faulty coordination between limbs and trunk, and the consequent inability to walk straight. In the present study, the cerebellar concentrations of glutamate and GABA were analyzed, since glutamate is a most prevalent excitatory neurotransmitter whereas gamma-aminobutyric acid (GABA) is one of the most abundant inhibitory neurotransmitters, which may be the main neurotransmitters related with the ataxia and epilepsy. The concentration of glutamate of cerebellum decreased significantly in ataxic mutant Pogo mouse compared to those of control mouse. However, GABA concentration was not decrease. These results suggested that the decrease in glutamate concentration may contribute to ataxia in mutant Pogo mouse.
Keyword
cerebellummousemouse mutantcerebellummicemice, mutant strains
ISSN
I000-0131
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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