Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer

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Title
Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer
Author(s)
Q L Li; H R Kim; W J Kim; J K Choi; Y H Lee; Hwan Mook Kim; L S Li; H G Kim; J Chang; Y Ito; K Y Lee; S C Bae
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 314, no. 1, pp. 223-228
Publication Year
2004
Abstract
RUNX family transcription factors are integral components of TGF-β signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. It was noted previously that allele loss and loss of expression of RUNX3 are causally involved in gastric carcinogenesis. Our results demonstrate that RUNX3 is inactivated by aberrant DNA methylation in approximately 19% of lung cancer cell lines and 24% of primary lung cancer specimens. RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer.
Keyword
lung cancermethylationRUNX3TGF-βtranscription
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2003.12.079
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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