DC Field | Value | Language |
---|---|---|
dc.contributor.author | E C Kim | - |
dc.contributor.author | Bong Sik Yun | - |
dc.contributor.author | In Ja Ryoo | - |
dc.contributor.author | Jeong Ki Min | - |
dc.contributor.author | M H Won | - |
dc.contributor.author | K S Lee | - |
dc.contributor.author | Y M Kim | - |
dc.contributor.author | Ick Dong Yoo | - |
dc.contributor.author | Y G Kwon | - |
dc.date.accessioned | 2017-04-19T09:00:49Z | - |
dc.date.available | 2017-04-19T09:00:49Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1016/j.bbrc.2003.11.104 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6412 | - |
dc.description.abstract | Complestatin, a bicyclo hexapeptide from Streptomyces, was isolated as a possible regulator of neuronal cell death. In this study, we report an anti-apoptotic activity of complestatin and its underlying molecular mechanism. Complestatin blocked TRAIL (TNF-related apoptosis-inducing ligand)-induced apoptosis and activation of caspase-3 and -8 at micromolar concentration levels without inhibiting the catalytic activities of these caspases. Complestatin potently induced a rapid and sustained AKT/PKB activation and Bad phosphorylation, resulting in inhibition of mitochondrial cytochrome c release. These anti-apoptotic activities of complestatin were significantly abrogated in cells expressing dominant negative AKT/PKB. Taken together, our results suggest that complestatin prevents apoptotic cell death via AKT/PKB-dependent inhibition of the mitochondrial apoptosis signal pathway. The novel property of complestatin may be valuable for developing new pharmaceutical means that will control unwanted cell death. | - |
dc.publisher | Elsevier | - |
dc.title | Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation | - |
dc.title.alternative | Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 204 | - |
dc.citation.startPage | 193 | - |
dc.citation.volume | 313 | - |
dc.contributor.affiliatedAuthor | Bong Sik Yun | - |
dc.contributor.affiliatedAuthor | In Ja Ryoo | - |
dc.contributor.affiliatedAuthor | Jeong Ki Min | - |
dc.contributor.affiliatedAuthor | Ick Dong Yoo | - |
dc.contributor.alternativeName | 김억천 | - |
dc.contributor.alternativeName | 윤봉식 | - |
dc.contributor.alternativeName | 류인자 | - |
dc.contributor.alternativeName | 민정기 | - |
dc.contributor.alternativeName | 원무호 | - |
dc.contributor.alternativeName | 이광순 | - |
dc.contributor.alternativeName | 김영명 | - |
dc.contributor.alternativeName | 유익동 | - |
dc.contributor.alternativeName | 권영근 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 313, no. 1, pp. 193-204 | - |
dc.identifier.doi | 10.1016/j.bbrc.2003.11.104 | - |
dc.subject.keyword | AKT/PKB | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Caspases | - |
dc.subject.keyword | Complestatin | - |
dc.subject.keyword | TRAIL | - |
dc.subject.local | AKT/PKB | - |
dc.subject.local | Akt/PKB | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | Caspase | - |
dc.subject.local | Caspases | - |
dc.subject.local | caspase | - |
dc.subject.local | complestatin | - |
dc.subject.local | Complestatin | - |
dc.subject.local | TRAIL | - |
dc.description.journalClass | Y | - |
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