Four weeks repeated toxicity study of 2-omega-Benzoylcinnamaldehyde(CB-PH) by oral administration in sprague-dawley rats = 랫드에서 계피유래활성물질(CB-PH)의 경구투여에 의한 4주간 반복투여독성 시험

Abstract

Although Cinnamon has been widely used for the food and biophamacy in the world,it's toxicity was not screened completely. Major component of cinnamon is CB-OH and CB-PH. CB-PH has been reported to have antimutagenic effect. To investigate the toxicity of 2-o-Benzoylcinnama-ldehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeateddose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PHtreated group showed no significant toxicological findings with body weights, organ weights, hemato-logical and histopathological findings. Therefore, these data indicated that the maximum tolerateddose of CB-PH was 2000 mg above/kg/day in the rats.