Screening of the inhibitory activity of medicinal plants against protein tyrosine phosphatase 1B = 생약의 protein tyrosine phosphatase 1B(PTP1B) 저해활성 검색

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Title
Screening of the inhibitory activity of medicinal plants against protein tyrosine phosphatase 1B = 생약의 protein tyrosine phosphatase 1B(PTP1B) 저해활성 검색
Author(s)
Jung Hyun Hong; Myung Sun Lee; Eun Young Bae; Y H Kim; Hyuncheol Oh; Won Keun Oh; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 35, no. 1, pp. 16-21
Publication Year
2004
Abstract
Protein tyrosine phosphatase 1B(PTP1B) is thought to be a negative regulator in insulin signal-transduction pathway. Insulin-resistance by the activation of PTP1B is a hallmark of both type 2 diabetes and obesity. Thus, the compounds inhibiting PTP1B can improve insulin resistance and can be effective in treating type 2 diabetes and obesity. The methanol extracts of 160 herbal medicines were screened for the inhibitory activity against PTP1B. Among the tested extracts, methanol extracts of Amsonia elliptica, Areca catechu, Benincasa hispida, Morus alba, Salvia miltiorrhiza, Siegesbeckia orientalis, and Trichosanthes kirilowii showed relatively strong inhibitory activity against PTP1B.
Keyword
insulinmedicinal plantsPTP1Btype II diabetes
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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