The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

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dc.contributor.authorJ H Kim-
dc.contributor.authorSun Young Yoon-
dc.contributor.authorC N Kim-
dc.contributor.authorJoung Hyuck Joo-
dc.contributor.authorS K Moon-
dc.contributor.authorIn Seong Choe-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorJae Wha Kim-
dc.date.accessioned2017-04-19T09:00:53Z-
dc.date.available2017-04-19T09:00:53Z-
dc.date.issued2004-
dc.identifier.issn0304-3835-
dc.identifier.uri10.1016/j.canlet.2003.07.009ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6436-
dc.description.abstractTo clarify the roles of Bmi-1 in colorectal carcinoma, we examined the expression of Bmi-1 in 41 samples out of 46 colorectal carcinomas by reverse transcription-PCR, whereas all 46 were analyzed by immunostaining. In addition, we analyzed the expression patterns of Bmi-1 in association with p16INK4a and p14ARF (in mouse p19ARF) in a series of colorectal carcinomas. The level of Bmi-1 mRNA in the carcinoma tissues was significantly higher than those of the adjacent non-neoplastic colonic mucosal tissues. Immunohistochemistry for Bmi-1 showed moderate or strong expression levels in 65% (30/46) of colorectal carcinomas. Colorectal carcinomas with moderate or strong Bmi-1 expression were more likely to have low levels of the INK4 locus proteins (p16INK4a/p14ARF) (P<0.07). These results suggested that modulation of Bmi-1 protein might be involved in human colorectal carcinogenesis by repressing the INK4a/ARF proteins.-
dc.publisherElsevier-
dc.titleThe Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins-
dc.title.alternativeThe Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins-
dc.typeArticle-
dc.citation.titleCancer Letters-
dc.citation.number2-
dc.citation.endPage224-
dc.citation.startPage217-
dc.citation.volume203-
dc.contributor.affiliatedAuthorSun Young Yoon-
dc.contributor.affiliatedAuthorJoung Hyuck Joo-
dc.contributor.affiliatedAuthorIn Seong Choe-
dc.contributor.affiliatedAuthorYong Kyung Choe-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.alternativeName김주헌-
dc.contributor.alternativeName윤선영-
dc.contributor.alternativeName김창남-
dc.contributor.alternativeName주종혁-
dc.contributor.alternativeName문상경-
dc.contributor.alternativeName최인성-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeName김재화-
dc.identifier.bibliographicCitationCancer Letters, vol. 203, no. 2, pp. 217-224-
dc.identifier.doi10.1016/j.canlet.2003.07.009-
dc.subject.keywordBmi-1-
dc.subject.keywordcolorectal carcinoma-
dc.subject.keywordp14ARF-
dc.subject.keywordp16INK4a-
dc.subject.keywordup-regulation-
dc.subject.localBmi-1-
dc.subject.localBmi1-
dc.subject.localColorectal carcinoma-
dc.subject.localcolorectal carcinoma-
dc.subject.localp14ARF-
dc.subject.localP16INK4A-
dc.subject.localp16INK4a-
dc.subject.localup-regulation-
dc.subject.localupregulation-
dc.subject.localUpregulation&-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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