Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells

Cited 73 time in scopus
Metadata Downloads
Title
Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells
Author(s)
J S Cho; Hyeong Kyu Lee
Bibliographic Citation
European Journal of Pharmacology, vol. 485, no. 1, pp. 105-110
Publication Year
2004
Abstract
The present study evaluated effects of wogonin (5,7-dihydroxy-8- methoxyflavone) on excitotoxic and oxidative stress-induced neuronal damage in primary cultured rat cortical cells. Wogonin was shown to inhibit the excitotoxicity induced by glutamate or N-methyl-D-aspartic acid, whereas it showed no effects on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- or kainate-induced toxicity. In addition, wogonin inhibited the oxidative neuronal damage induced by H2O2, xanthine/xanthine oxidase, and by a glutathione depleting agent D,L-buthionine [S,R]-sulfoximine. Furthermore, wogonin dramatically inhibited lipid peroxidation initiated by Fe2+ and L-ascorbic acid in rat brain homogenates. It also exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Taken together, these results demonstrate that wogonin exhibits neuroprotective actions in cultured cortical cells by inhibiting excitotoxicity and various types of oxidative stress-induced damage, and that its antioxidant actions with radical scavenging activity may contribute, at least in part, to the neuroprotective effects.
Keyword
antioxidantcortical neuronexcitotoxicityneuroprotectionoxidative damagewogonin
ISSN
0014-2999
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ejphar.2003.11.064
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.