Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction

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dc.contributor.authorY H Choi-
dc.contributor.authorH I Kim-
dc.contributor.authorJ K Seong-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorH S Cho-
dc.contributor.authorM O Lee-
dc.contributor.authorJ M Lee-
dc.contributor.authorY H Ahn-
dc.contributor.authorS J Kim-
dc.contributor.authorJ H Park-
dc.date.accessioned2017-04-19T09:00:53Z-
dc.date.available2017-04-19T09:00:53Z-
dc.date.issued2004-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/S0014-5793(03)01449-2ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6441-
dc.description.abstractLigand activation of peroxisome proliferator-activated receptor γ (PPARγ) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARγ activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARγ ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARγ and HBx/PPARγ interaction blocked nuclear localization and binding to recognition site of PPARγ. HBx significantly suppressed a PPARγ-mediated transactivation. These results suggest that HBx modulates PPARγ function through protein-protein interaction.-
dc.publisherWiley-
dc.titleHepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction-
dc.title.alternativeHepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number1-
dc.citation.endPage80-
dc.citation.startPage73-
dc.citation.volume557-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName최연희-
dc.contributor.alternativeName김하일-
dc.contributor.alternativeName성제경-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName조혜성-
dc.contributor.alternativeName이미옥-
dc.contributor.alternativeName이재면-
dc.contributor.alternativeName안용호-
dc.contributor.alternativeName김세종-
dc.contributor.alternativeName박전한-
dc.identifier.bibliographicCitationFEBS Letters, vol. 557, no. 1, pp. 73-80-
dc.identifier.doi10.1016/S0014-5793(03)01449-2-
dc.subject.keywordHepatitis B virus X protein-
dc.subject.keywordPeroxisome proliferator-activated receptor γ-
dc.subject.keywordProtein-protein interaction-
dc.subject.keywordTransactivation-
dc.subject.localhepatitis B virus X protein-
dc.subject.localHepatitis B virus-X protein-
dc.subject.localHepatitis B virus X protein-
dc.subject.localhepatitis B virus-X protein-
dc.subject.localHepatitis B virus X-protein-
dc.subject.localPeroxisome proliferator-activated receptor γ-
dc.subject.localperoxisome proliferators-activated receptor γ-
dc.subject.localProtein-protein interaction-
dc.subject.localProteinprotein interactions-
dc.subject.localProtein-Protein Interaction-
dc.subject.localProtein-Protein interaction-
dc.subject.localprotein-protein interaction-
dc.subject.localProtein-protein interactions-
dc.subject.localTransactivation-
dc.subject.localtransactivation-
dc.description.journalClassY-
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