In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens

Cited 49 time in scopus
Metadata Downloads
Title
In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens
Author(s)
Mi Yeon Chung; Mun Chual Rho; Jeong Suk Ko; S Y Ryu; K H Jeune; K H Kim; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Planta Medica, vol. 70, no. 3, pp. 258-260
Publication Year
2004
Abstract
Four prenylflavonoids, kurarinone (1), a chalcone of 1, kuraridin (2), kurarinol (3), kushenol H (4) and kushenol K (5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 μM (1), 9.8 μM (2), 8.6 μM (3), 142.0 μM (4) and 250 μM (5). The prenylflavonoids without C3-OH (1,2,3) showed stronger inhibition than those with C3-OH (4,5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 μM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-815545
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.