PPAR α activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells

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dc.contributor.authorSung Woo Ryoo-
dc.contributor.authorMi Sun Won-
dc.contributor.authorDong Uk Kim-
dc.contributor.authorLila Kim-
dc.contributor.authorGyoon Hee Han-
dc.contributor.authorS K Park-
dc.contributor.authorN Mukaida-
dc.contributor.authorP J Maeng-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorKwang Lae Hoe-
dc.date.accessioned2017-04-19T09:00:59Z-
dc.date.available2017-04-19T09:00:59Z-
dc.date.issued2004-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2004.04.031ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6459-
dc.description.abstractNative low density lipoprotein (n-LDL) is a major risk factor for cardiovascular diseases by inducing inflammatory processes and vascular smooth muscle cell proliferation in vessel cells. It has previously been reported that LDL enhances inflammatory reactions by the up-regulation of interleukin (IL)-8 via the activation of p38 kinase and activator protein (AP)-1 in human aortic smooth muscle cells (hAoSMCs). The findings of this study show, for the first time, that the peroxisome proliferator-activated receptor (PPARα) agonist, fenofibrate, completely abolishes the LDL-induced IL-8 up-regulation at the transcriptional level. Pretreatment of hAoSMCs with fenofibrate abolishes the effects of LDL on AP-1 activation without affecting nuclear factor (NF)-κB. In contrast, fenofibrate failed to modulate the activation state of p38 and JNK kinases or the levels of c-fos and phospho-Jun. These data suggest that AP-1 is likely to be located at the crossroads between LDL signaling and the regulation of IL-8 modulation by PPARα.-
dc.publisherElsevier-
dc.titlePPAR α activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells-
dc.title.alternativePPAR α activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage334-
dc.citation.startPage329-
dc.citation.volume318-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.affiliatedAuthorDong Uk Kim-
dc.contributor.affiliatedAuthorLila Kim-
dc.contributor.affiliatedAuthorGyoon Hee Han-
dc.contributor.affiliatedAuthorHyang Sook Yoo-
dc.contributor.affiliatedAuthorKwang Lae Hoe-
dc.contributor.alternativeName유성우-
dc.contributor.alternativeName원미선-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeName김리라-
dc.contributor.alternativeName한균희-
dc.contributor.alternativeName박승길-
dc.contributor.alternativeNameMukaida-
dc.contributor.alternativeName맹필재-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName허광래-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 318, no. 2, pp. 329-334-
dc.identifier.doi10.1016/j.bbrc.2004.04.031-
dc.subject.keywordAP-1-
dc.subject.keywordfenofibrate-
dc.subject.keywordinterleukin-8-
dc.subject.keywordlow-density lipoprotein-
dc.subject.keywordPPAR-
dc.subject.keywordsmooth muscle cell-
dc.subject.localAP-1-
dc.subject.localFenofibrate-
dc.subject.localfenofibrate-
dc.subject.localinterleukin-8-
dc.subject.localInterleukin-8-
dc.subject.localLow-density lipoprotein-
dc.subject.locallow-density lipoproteins-
dc.subject.localLow-density lipoprotein (LDL)-
dc.subject.localLow-density lipoproteins-
dc.subject.locallow-density lipoprotein-
dc.subject.localPPAR-
dc.subject.localSmooth muscle cell-
dc.subject.localsmooth muscle cell-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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