Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors

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Title
Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors
Author(s)
Tae Sook Jeong; Kyung Soon Kim; So Jin An; Kyung Hyun Cho; Sangku LeeWoo Song Lee
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 11, pp. 2715-2717
Publication Year
2004
Abstract
A series of pyrazoline derivatives were prepared for evaluating their acyl-CoA:cholesterol acyltransferase activities. 3-(3,5-Di-tert-butyl-4- hydroxyphenyl)-5-(multi-substituted 4-hydroxyphenyl)-2-pyrazolines 4a-i were shown in vitro inhibitory activity on hACAT-1 and -2.
Keyword
ACAT inhibitor
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2004.03.079
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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