Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor

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dc.contributor.authorTae Sook Jeong-
dc.contributor.authorKyung Soon Kim-
dc.contributor.authorJu Ryoung Kim-
dc.contributor.authorKyung Hyun Cho-
dc.contributor.authorSangku Lee-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-04-19T09:01:03Z-
dc.date.available2017-04-19T09:01:03Z-
dc.date.issued2004-
dc.identifier.issn0960894X-
dc.identifier.uri10.1016/j.bmcl.2004.03.072ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6481-
dc.description.abstractCompounds 4a-j and 5 were synthesized by cyclocondensation of 3a-j and hydrazine and showed significant LDL-antioxidant activities in the TBARS assay, the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation, and the macrophage-mediated LDL oxidation. Among compounds 4a-j and 5, 4a was found to be the most active compound as an inhibitor of LDL oxidation and 4a (IC 50=0.1μM) was 6-fold more potent than probucol (IC 50=0.6μM) in the TBARS assay.-
dc.publisherElsevier-
dc.titleNovel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor-
dc.title.alternativeNovel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number11-
dc.citation.endPage2723-
dc.citation.startPage2719-
dc.citation.volume14-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName김경순-
dc.contributor.alternativeName김주령-
dc.contributor.alternativeName조경현-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 14, no. 11, pp. 2719-2723-
dc.identifier.doi10.1016/j.bmcl.2004.03.072-
dc.subject.keywordLDL-antioxidant-
dc.subject.localLDL-antioxidant-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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