Relationship between flavonoid structure and inhibition of farnesyl protein transferase

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dc.contributor.authorHyun Mi Kang-
dc.contributor.authorJong Han Kim-
dc.contributor.authorMi Young Lee-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorD C Yang-
dc.contributor.authorN I Baek-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:01:05Z-
dc.date.available2017-04-19T09:01:05Z-
dc.date.issued2004-
dc.identifier.issn1029-2349-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6493-
dc.description.abstractFlavonoids are well-known phytochemicals that are produced by various plants in high quantities. The chemopreventive activity of flavonoids is dependent on their structural features. The studies of structure-FPTase inhibitory activity indicated that the number, position and substitution of hydroxyl groups of the A and B rings of flavonoid, and unsaturation of the C2-C3 bond are important factors affecting inhibition on FPTase by flavonoids. A couple of flavonoids inhibited FPTase and also the growth of human tumor cell lines, especially butein, which strongly inhibited the growth of colon cancer cell line (HCT116). However, flavanones and flavanols did not inhibit FPTase nor the growth of tumor cells.-
dc.publisherT&F (Taylor & Francis)-
dc.titleRelationship between flavonoid structure and inhibition of farnesyl protein transferase-
dc.title.alternativeRelationship between flavonoid structure and inhibition of farnesyl protein transferase-
dc.typeArticle-
dc.citation.titleNatural Product Research-
dc.citation.number4-
dc.citation.endPage356-
dc.citation.startPage349-
dc.citation.volume18-
dc.contributor.affiliatedAuthorHyun Mi Kang-
dc.contributor.affiliatedAuthorJong Han Kim-
dc.contributor.affiliatedAuthorMi Young Lee-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName강현미-
dc.contributor.alternativeName김종한-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName양덕조-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationNatural Product Research, vol. 18, no. 4, pp. 349-356-
dc.identifier.doi10.1080/14786410310001622022-
dc.subject.keywordcell proliferation assay-
dc.subject.keywordfarnesyl protein transferase-
dc.subject.keywordflavonoid-
dc.subject.keywordstructure-activity relationship-
dc.subject.localcell proliferation assay-
dc.subject.localFarnesyl protein transferase-
dc.subject.localfarnesyl protein transferase-
dc.subject.localFarnesyl-protein transferase (FPTase)-
dc.subject.localFlavonoids-
dc.subject.localflavonoid-
dc.subject.localflavonoids-
dc.subject.localFlavonoid-
dc.subject.localstructure-activity relationships-
dc.subject.localStructure-activity relationship-
dc.subject.localstructureactivity relationships-
dc.subject.localStructure-activity relationships-
dc.subject.localstructure-activity relationship-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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