DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyun Mi Kang | - |
dc.contributor.author | Jong Han Kim | - |
dc.contributor.author | Mi Young Lee | - |
dc.contributor.author | Kwang Hee Son | - |
dc.contributor.author | D C Yang | - |
dc.contributor.author | N I Baek | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.date.accessioned | 2017-04-19T09:01:05Z | - |
dc.date.available | 2017-04-19T09:01:05Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1029-2349 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6493 | - |
dc.description.abstract | Flavonoids are well-known phytochemicals that are produced by various plants in high quantities. The chemopreventive activity of flavonoids is dependent on their structural features. The studies of structure-FPTase inhibitory activity indicated that the number, position and substitution of hydroxyl groups of the A and B rings of flavonoid, and unsaturation of the C2-C3 bond are important factors affecting inhibition on FPTase by flavonoids. A couple of flavonoids inhibited FPTase and also the growth of human tumor cell lines, especially butein, which strongly inhibited the growth of colon cancer cell line (HCT116). However, flavanones and flavanols did not inhibit FPTase nor the growth of tumor cells. | - |
dc.publisher | T&F (Taylor & Francis) | - |
dc.title | Relationship between flavonoid structure and inhibition of farnesyl protein transferase | - |
dc.title.alternative | Relationship between flavonoid structure and inhibition of farnesyl protein transferase | - |
dc.type | Article | - |
dc.citation.title | Natural Product Research | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 356 | - |
dc.citation.startPage | 349 | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Hyun Mi Kang | - |
dc.contributor.affiliatedAuthor | Jong Han Kim | - |
dc.contributor.affiliatedAuthor | Mi Young Lee | - |
dc.contributor.affiliatedAuthor | Kwang Hee Son | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 강현미 | - |
dc.contributor.alternativeName | 김종한 | - |
dc.contributor.alternativeName | 이미영 | - |
dc.contributor.alternativeName | 손광희 | - |
dc.contributor.alternativeName | 양덕조 | - |
dc.contributor.alternativeName | 백남인 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.identifier.bibliographicCitation | Natural Product Research, vol. 18, no. 4, pp. 349-356 | - |
dc.identifier.doi | 10.1080/14786410310001622022 | - |
dc.subject.keyword | cell proliferation assay | - |
dc.subject.keyword | farnesyl protein transferase | - |
dc.subject.keyword | flavonoid | - |
dc.subject.keyword | structure-activity relationship | - |
dc.subject.local | cell proliferation assay | - |
dc.subject.local | Farnesyl protein transferase | - |
dc.subject.local | farnesyl protein transferase | - |
dc.subject.local | Farnesyl-protein transferase (FPTase) | - |
dc.subject.local | Flavonoids | - |
dc.subject.local | flavonoid | - |
dc.subject.local | flavonoids | - |
dc.subject.local | Flavonoid | - |
dc.subject.local | structure-activity relationships | - |
dc.subject.local | Structure-activity relationship | - |
dc.subject.local | structureactivity relationships | - |
dc.subject.local | Structure-activity relationships | - |
dc.subject.local | structure-activity relationship | - |
dc.description.journalClass | Y | - |
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